The incidence of bleeding with the higher target INRs was not higher than with the lower ranges OR 2. Aspirin could prevent 17 strokes, without increasing major hemorrhage.
Patients on low molecular weight heparin had an OR for stroke of 0.
In the SPAF II study, the patients under 75 years old had a greater absolute mortality benefit with warfarin than did the older group.
The aggregate OR for minor hemorrhage was 2.
Stroke prevention in atrial fibrillation study. Notably, a number of the studies were terminated prematurely owing to the high incidence of stroke in the less-intensive arm or, when proof of efficacy was met.
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